Immortality Discovered

Im a BM wrote:

Spongy Iris wrote:

Im a BM wrote:

Spongy Iris wrote:

Im a BM wrote:

Spongy Iris wrote:

Im a BM wrote:

I'm going to shift my rejection of the dominant theory from "implausible" to "unlikely".

The challenge in natural selection when vertebrates evolve to insert a penis into a pouch for fertilization, rather than blow a load in open water, just millimeters from the target eggs.

Those sperm cells have to stay alive and keep swimming far enough to find the egg hidden deep in the female fun pouch. Nature's first iteration of the vagina was called a "sewer" in latin ("cloaca"), because a single orifice was used for shitting, pissing, and boning. Not the cleanest place for a load of semen to find itself in. Plenty of microorganisms, aerobic and anaerobic, could find their way in there if they aren't already growing there.

So, I shift my skepticism from "implausible" to "unlikely" to consider how natural selection not only favored providing an energy source in the semen for the hours-long journey, it also favored using a sugar less likely to result in toxic shock from rotting upon decomposition by microorganisms.

It required a DOUBLE leap. Sperm cells had to mutate to be able to use fructose, and glands had to mutate/evolve to produce fructose and add it to the semen. I'm not saying it is impossible, but there may be a simpler explanation.

I think semen is what hijacks sperm to transport it, otherwise it wouldn't leave the body.

So semen seems like the overall preservative during transport. I think for now I'm gonna stick with the idea that fructose is more significant for its use as fuel for growth than it is the main preservative of sperm traveling to impregnate an egg.

Fructose is a good food preservative, but I think something like 95% of an ejaculate is semen, so this seems like the main line of defense against microorganisms during transport.

That said, my position is the best preservative of sperm is not to transport it, but retain it. Do that for long enough, and I think all semen will get excreted as waste, no longer serving any purpose.

I forgot to mention the PROSTATE CANCER connection to fructose in semen.

Prostate cancer doesn't render men incapable of reproducing until well after the age they should have already fathered children. Humans didn't even live long enough to get prostate cancer in most cases. It is no risk to reproductive success to have a self destructive trait in the related genes, as long as it doesn't bring on the cancer until late in life.

What does Google say in response to the inquiry: "Prostate cancer and fructose in semen"?

Google say: "In healthy men, seminal fructose is a vital energy source for sperm motility and is produced primarily by the seminal vesicles. For men with prostate cancer, however, research indicates that these cancer cells can upregulate certain fructose transporters (like Glut5) to utilize fructose as an alternative metabolic fuel source, which promotes tumor growth and agressiveness."

Our seminal vesicles supply the prostate cancer with the fuel to kill us with.

As the genius evolutionary biologist Richard Dawkins pointed out, late-acting lethal genes cannot be selected against in evolution if they don't kick in until after the organism has passed peak reproductive age.

As social animals, humans have another reproductive success variable that extends beyond peak reproductive years. Post menopausal women may not be able to have more babies, but they can care for grandchildren and thereby further enhance their reproductive success. This may have even helped select AGAINST some of those late-acting lethal genes. We live a LOT longer than most mammals, and even longer than most social mammals.

Selection against prostate cancer could arise from older men maintaining their position of wealth and power in society, with greater reproductive success for their progeny arising from their increased longevity, decades after they no longer father any new children.

It becomes a chicken and egg question, quite literally, in evolutionary biology.

I love high fructose corn syrup. Sprite or 7up are my favorites.

Fructose is synthesized just in the liver, and doesn't trigger insulin production like glucose does.

Looks like we have come full circle to my starting position of the thread: cancer being the key to immortality.

Cancer cells can split without losing telomere length, thus they can regenerate indefinitely.

Everybody who lives long enough will get cancer.

And studies indicate, men who ejaculate less trigger prostate cancer sooner in life.

By quitting orgasms altogether, it seems the body can develop a urea shield, to protect against the acidic nature of cancer cells, allowing for a successful union of cancer cells with the human body.

As touched upon in our latest tangent, it seems there is a link between sperm or eggs and cancer. Coincidentally, or perhaps the phrase synchronistically works better, the numerical symbol for cancer is 69.

150 new "Views" in a day and a half. This thread is getting more attention than any New Messiah threads did in the past week. It appears that those who merely look far outnumber those who actually post anything.

I'm not convinced that a "urea shield" is particularly helpful. Uric acid forms troublesome crystals that can cause gout, among other problems. When the interstitium gets dried out somewhere to the point of desperately sucking in urine as a source of water, it is not a healthy sign. The body makes the effort to get rid of urea because it is toxic, although far less toxic than uric acid or ammonia. That excess amino nitrogen from our protein-rich diets gets expelled as urea because there is nothing of value the body can do with it, and it has harmful side effects.

Fructose is in our diet, as free sugar in fruit, etc. Fructose is also released when sucrose is broken into its fructose and glucose subunits. The liver is where fructose taken into our guts can be METABOLIZED (rather than synthesized). Other than liver cells, sperm cells are just about the only ones in the body that can use fructose.

Buffering against acid is usually accomplished in the body using bicarbonate ion.

Your urea as an acid buffer theory puzzles me in terms of chemical mechanism.

Ah yes... metabolized.

Perhaps consider...

Helicobacter pylori (H. pylori) is the bacteria in the stomach that survives the stomach's harsh, acidic environment by producing an enzyme called urease. This enzyme breaks down the urea naturally present... creating ammonia and carbon dioxide. The ammonia forms a localized cloud that neutralizes the surrounding stomach acid, allowing the bacteria to thrive.

The indications I consider, showing somehow a urease shield is now working for me, instead of against me, is I have cured my acid reflux, and my skin is softer and more golden now.

Your point about urea makes sense now.

In soil, microsites of urease activity can drive pH to >10.

Ammonium hydroxide is the base generated,

CO(NH2)2 + 3H2O = 2NH4+ + 2OH- + CO2 or
CO(NH2)2 + 3H2O = 2NH4OH + CO2
urea plus water makes ammonium hydroxide and carbon dioxide

But in the presence of carbon dioxide, half the ammonium hydroxide basicity is neutralized.

NH4OH + CO2 = NH4HCO3
ammonium hydroxide plus carbon dioxide makes ammonium bicarbonate.

Of course, stomach acid is very strong, and as soon as it hits the ammonium bicarbonate it turns it to carbon dioxide

HCl + NH4HCO3 = NH4Cl + H2O + CO2
hydrochloric acid plus ammonium bicarbonate makes ammonium chloride plus water plus carbon dioxide.

Where urea fails to "protect" the stomach from acid is when it generates ammonia, which is FAR more toxic to us than urea or uric acid.

On the other hand, a free agent bacteria might not mind the ammonia at all as it creates higher pH microsites for itself by employing the urease enzyme.

On the other hand, I wasn't aware we had much urea in our stomachs. I thought our kidneys were taking it out of the blood to send it to the bladder.

Okay, I looked it up. Yes, small amounts of urea leak into the gastric juices from the bloodstream and get into the stomach. And yes, Helicobacter pylori can create microsites of higher pH for itself by making urease. I bet that if I look deeper, I'll find that the ammonia generated can cause stomach ulcers.

So I looked it up. Google says: "Yes, the ammonia produced by Helicobacter pylori plays a major role in its ability to cause stomach ulcers."

This bacteria sounds more like a harmful parasite than a symbiotic partner in our digestive tract.

I guess what I'm really trying to say is GOOGLE IS GOD!

sealover wrote:

My newest medical science hypothesis:

Most people do not have stomach ulcers from Helicobacter pylori growing inside them. Most people do not have enough urea in their gastric fluid to make it possible for a population of Helicobacter pylori to create conditions of elevated pH by putting out urease enzyme into the fluid around them.

It is not a healthy individual who has enough urea getting into his gastric fluid to enable a population of Helicobacter pylori to establish in his gut. The kidneys are supposed to remove urea from the blood and send it to the bladder. The blood in close proximity to the cells that put out gastric fluid should not contain high enough concentrations of urea that gastric fluids contain enough urea to support the urease activities of Helicobacter pylori.

One obvious potential explanation is kidney dysfunction. If the kidneys aren't removing urea from the blood effectively, relatively high concentrations may be in the blood near gastric fluid producing cells.

Another less obvious cause, but one that I am certain accounts for my own issues, is that urea from URINE is getting in where it should not go. Urea in the bladder has already been separated from the blood and should be on its way out of the body. Bladder urine adjacent cells are in contact with high concentrations of urea. Urea from urine can get sucked back into body through other tissues. Some of that urea can find its way to be in close proximity to the cells that produce gastric fluids.

High blood concentrations of urea could account for Helicobacter pylori establishing in persons whose kidneys are failing to remove urea effectively.

Normal, healthy and low concentrations of urea in blood may not exempt others from colonization by Helicobacter pylori wreaking havoc in their guts. They may have urea leaking out of their own urine that supplies the bacteria with the substrate it needs to raise pH with urease. I blame the interstitium for failing in many such instances. This interconnected network of fluid-filled compartments requires constant input of water. It will pull water out from any nearby tissue if it gets desperate. Even if that water is urine. Urine is loaded with urea.

That will get me my Nobel Prize in medicine!

Spongy Iris wrote:

sealover wrote:

My newest medical science hypothesis:

Most people do not have stomach ulcers from Helicobacter pylori growing inside them. Most people do not have enough urea in their gastric fluid to make it possible for a population of Helicobacter pylori to create conditions of elevated pH by putting out urease enzyme into the fluid around them.

It is not a healthy individual who has enough urea getting into his gastric fluid to enable a population of Helicobacter pylori to establish in his gut. The kidneys are supposed to remove urea from the blood and send it to the bladder. The blood in close proximity to the cells that put out gastric fluid should not contain high enough concentrations of urea that gastric fluids contain enough urea to support the urease activities of Helicobacter pylori.

One obvious potential explanation is kidney dysfunction. If the kidneys aren't removing urea from the blood effectively, relatively high concentrations may be in the blood near gastric fluid producing cells.

Another less obvious cause, but one that I am certain accounts for my own issues, is that urea from URINE is getting in where it should not go. Urea in the bladder has already been separated from the blood and should be on its way out of the body. Bladder urine adjacent cells are in contact with high concentrations of urea. Urea from urine can get sucked back into body through other tissues. Some of that urea can find its way to be in close proximity to the cells that produce gastric fluids.

High blood concentrations of urea could account for Helicobacter pylori establishing in persons whose kidneys are failing to remove urea effectively.

Normal, healthy and low concentrations of urea in blood may not exempt others from colonization by Helicobacter pylori wreaking havoc in their guts. They may have urea leaking out of their own urine that supplies the bacteria with the substrate it needs to raise pH with urease. I blame the interstitium for failing in many such instances. This interconnected network of fluid-filled compartments requires constant input of water. It will pull water out from any nearby tissue if it gets desperate. Even if that water is urine. Urine is loaded with urea.

That will get me my Nobel Prize in medicine!

I'm not sure I would claim helicobacter pylori to be the universal bad bacteria of the stomach and digestive system. ChatGPT is the tool that first named this bacteria for me during a chat.

But I am sure, almost universally, yes, everybody has bad bacteria and other parasites taking the piss, causing accumulation in undesirable locations, such as the stomach. In the feet causing gout is another example mentioned earlier.

One thing everybody probably notices about orgasms and lust, is they really feel like getting your guts tied into knots. It's like twisting shit for the purpose of feeding it.

Im a BM wrote:

Spongy Iris wrote:

sealover wrote:

My newest medical science hypothesis:

Most people do not have stomach ulcers from Helicobacter pylori growing inside them. Most people do not have enough urea in their gastric fluid to make it possible for a population of Helicobacter pylori to create conditions of elevated pH by putting out urease enzyme into the fluid around them.

It is not a healthy individual who has enough urea getting into his gastric fluid to enable a population of Helicobacter pylori to establish in his gut. The kidneys are supposed to remove urea from the blood and send it to the bladder. The blood in close proximity to the cells that put out gastric fluid should not contain high enough concentrations of urea that gastric fluids contain enough urea to support the urease activities of Helicobacter pylori.

One obvious potential explanation is kidney dysfunction. If the kidneys aren't removing urea from the blood effectively, relatively high concentrations may be in the blood near gastric fluid producing cells.

Another less obvious cause, but one that I am certain accounts for my own issues, is that urea from URINE is getting in where it should not go. Urea in the bladder has already been separated from the blood and should be on its way out of the body. Bladder urine adjacent cells are in contact with high concentrations of urea. Urea from urine can get sucked back into body through other tissues. Some of that urea can find its way to be in close proximity to the cells that produce gastric fluids.

High blood concentrations of urea could account for Helicobacter pylori establishing in persons whose kidneys are failing to remove urea effectively.

Normal, healthy and low concentrations of urea in blood may not exempt others from colonization by Helicobacter pylori wreaking havoc in their guts. They may have urea leaking out of their own urine that supplies the bacteria with the substrate it needs to raise pH with urease. I blame the interstitium for failing in many such instances. This interconnected network of fluid-filled compartments requires constant input of water. It will pull water out from any nearby tissue if it gets desperate. Even if that water is urine. Urine is loaded with urea.

That will get me my Nobel Prize in medicine!

I'm not sure I would claim helicobacter pylori to be the universal bad bacteria of the stomach and digestive system. ChatGPT is the tool that first named this bacteria for me during a chat.

But I am sure, almost universally, yes, everybody has bad bacteria and other parasites taking the piss, causing accumulation in undesirable locations, such as the stomach. In the feet causing gout is another example mentioned earlier.

One thing everybody probably notices about orgasms and lust, is they really feel like getting your guts tied into knots. It's like twisting shit for the purpose of feeding it.

Although I studied the phenomenon very closely with observations of what someone else experienced, I cannot speak with direct knowledge of what distinguishes a female orgasm from a male orgasm.

I DO know that during the handful of seconds before a male orgasm, the interstitium is active in ways it is not at any other time. Having seen women briefly lose consciousness during the experience, or have temporary hearing loss immediately afterward, I suspect that something similar happens. Those fluid filled compartments get active in a way they do not at any other time. The diameter of some of the tubing widens like no other time, opening blockages very briefly and allowing movement of material that otherwise would never move.

Spongy Iris wrote:

Im a BM wrote:

Spongy Iris wrote:

sealover wrote:

My newest medical science hypothesis:

Most people do not have stomach ulcers from Helicobacter pylori growing inside them. Most people do not have enough urea in their gastric fluid to make it possible for a population of Helicobacter pylori to create conditions of elevated pH by putting out urease enzyme into the fluid around them.

It is not a healthy individual who has enough urea getting into his gastric fluid to enable a population of Helicobacter pylori to establish in his gut. The kidneys are supposed to remove urea from the blood and send it to the bladder. The blood in close proximity to the cells that put out gastric fluid should not contain high enough concentrations of urea that gastric fluids contain enough urea to support the urease activities of Helicobacter pylori.

One obvious potential explanation is kidney dysfunction. If the kidneys aren't removing urea from the blood effectively, relatively high concentrations may be in the blood near gastric fluid producing cells.

Another less obvious cause, but one that I am certain accounts for my own issues, is that urea from URINE is getting in where it should not go. Urea in the bladder has already been separated from the blood and should be on its way out of the body. Bladder urine adjacent cells are in contact with high concentrations of urea. Urea from urine can get sucked back into body through other tissues. Some of that urea can find its way to be in close proximity to the cells that produce gastric fluids.

High blood concentrations of urea could account for Helicobacter pylori establishing in persons whose kidneys are failing to remove urea effectively.

Normal, healthy and low concentrations of urea in blood may not exempt others from colonization by Helicobacter pylori wreaking havoc in their guts. They may have urea leaking out of their own urine that supplies the bacteria with the substrate it needs to raise pH with urease. I blame the interstitium for failing in many such instances. This interconnected network of fluid-filled compartments requires constant input of water. It will pull water out from any nearby tissue if it gets desperate. Even if that water is urine. Urine is loaded with urea.

That will get me my Nobel Prize in medicine!

I'm not sure I would claim helicobacter pylori to be the universal bad bacteria of the stomach and digestive system. ChatGPT is the tool that first named this bacteria for me during a chat.

But I am sure, almost universally, yes, everybody has bad bacteria and other parasites taking the piss, causing accumulation in undesirable locations, such as the stomach. In the feet causing gout is another example mentioned earlier.

One thing everybody probably notices about orgasms and lust, is they really feel like getting your guts tied into knots. It's like twisting shit for the purpose of feeding it.

Although I studied the phenomenon very closely with observations of what someone else experienced, I cannot speak with direct knowledge of what distinguishes a female orgasm from a male orgasm.

I DO know that during the handful of seconds before a male orgasm, the interstitium is active in ways it is not at any other time. Having seen women briefly lose consciousness during the experience, or have temporary hearing loss immediately afterward, I suspect that something similar happens. Those fluid filled compartments get active in a way they do not at any other time. The diameter of some of the tubing widens like no other time, opening blockages very briefly and allowing movement of material that otherwise would never move.

The female orgasm lasts longer than the male orgasm.

Perhaps it is because women tend to have more discipline than men, can usually abstain from orgasms for longer periods. Perhaps there is another physiological reason too.

I hear lesbian women are not as disciplined in this regard, as heterosexual women. Thus it is no surprise, the life expectancy of lesbians is significantly lower than heterosexual women.

It is also no surprise that the founder of OnlyFans only made it to 43. And in hindsight, no surprise I started suffering heart failure at 41.

Im a BM wrote:

Spongy Iris wrote:

Im a BM wrote:

Spongy Iris wrote:

sealover wrote:

My newest medical science hypothesis:

Most people do not have stomach ulcers from Helicobacter pylori growing inside them. Most people do not have enough urea in their gastric fluid to make it possible for a population of Helicobacter pylori to create conditions of elevated pH by putting out urease enzyme into the fluid around them.

It is not a healthy individual who has enough urea getting into his gastric fluid to enable a population of Helicobacter pylori to establish in his gut. The kidneys are supposed to remove urea from the blood and send it to the bladder. The blood in close proximity to the cells that put out gastric fluid should not contain high enough concentrations of urea that gastric fluids contain enough urea to support the urease activities of Helicobacter pylori.

One obvious potential explanation is kidney dysfunction. If the kidneys aren't removing urea from the blood effectively, relatively high concentrations may be in the blood near gastric fluid producing cells.

Another less obvious cause, but one that I am certain accounts for my own issues, is that urea from URINE is getting in where it should not go. Urea in the bladder has already been separated from the blood and should be on its way out of the body. Bladder urine adjacent cells are in contact with high concentrations of urea. Urea from urine can get sucked back into body through other tissues. Some of that urea can find its way to be in close proximity to the cells that produce gastric fluids.

High blood concentrations of urea could account for Helicobacter pylori establishing in persons whose kidneys are failing to remove urea effectively.

Normal, healthy and low concentrations of urea in blood may not exempt others from colonization by Helicobacter pylori wreaking havoc in their guts. They may have urea leaking out of their own urine that supplies the bacteria with the substrate it needs to raise pH with urease. I blame the interstitium for failing in many such instances. This interconnected network of fluid-filled compartments requires constant input of water. It will pull water out from any nearby tissue if it gets desperate. Even if that water is urine. Urine is loaded with urea.

That will get me my Nobel Prize in medicine!

I'm not sure I would claim helicobacter pylori to be the universal bad bacteria of the stomach and digestive system. ChatGPT is the tool that first named this bacteria for me during a chat.

But I am sure, almost universally, yes, everybody has bad bacteria and other parasites taking the piss, causing accumulation in undesirable locations, such as the stomach. In the feet causing gout is another example mentioned earlier.

One thing everybody probably notices about orgasms and lust, is they really feel like getting your guts tied into knots. It's like twisting shit for the purpose of feeding it.

Although I studied the phenomenon very closely with observations of what someone else experienced, I cannot speak with direct knowledge of what distinguishes a female orgasm from a male orgasm.

I DO know that during the handful of seconds before a male orgasm, the interstitium is active in ways it is not at any other time. Having seen women briefly lose consciousness during the experience, or have temporary hearing loss immediately afterward, I suspect that something similar happens. Those fluid filled compartments get active in a way they do not at any other time. The diameter of some of the tubing widens like no other time, opening blockages very briefly and allowing movement of material that otherwise would never move.

The female orgasm lasts longer than the male orgasm.

Perhaps it is because women tend to have more discipline than men, can usually abstain from orgasms for longer periods. Perhaps there is another physiological reason too.

I hear lesbian women are not as disciplined in this regard, as heterosexual women. Thus it is no surprise, the life expectancy of lesbians is significantly lower than heterosexual women.

It is also no surprise that the founder of OnlyFans only made it to 43. And in hindsight, no surprise I started suffering heart failure at 41.

This thread has gotten 300 "Views" in three days.

That is a whole lot more interest displayed than the mere dozen views a day threads by the New Messiah were getting. It is not random distribution.

But it is not the level of interest I seek before presenting a full discussion of that new "organ" they discovered throughout the human body, called "interstitium".

We will see how the "views" fluctuate in the coming days.

Last year, for some reason, 4th of July weekend was a HUGE one for threads on this website racking up hundreds of views per day, each. Well, the biogeochemistry-related threads, in any case. It wasn't random distribution back then either.

I await more clues to see if the "target audience" awaits more posts.

It's fine with me if it is only a few dozen appropriately-trained scientists, but I'm not sure they are here yet.

Spongy Iris wrote:
Bump with a song about the subject matter.

Saying goodbye to your soul.

Don't look back in anger by Oasis.

https://youtube.com/shorts/45qo_ksJlUw?si=U1I5HioBnVTdOFRy

Into the Night wrote:

Im a BM wrote:
One revolutionary movement in medical science research is to FINALLY understand what the single largest organ in the body really does.

People already know, Robert. Obviously, YOU DON'T.

Im a BM wrote:
"Connective" tissue does indeed connect everything to everything else in the body. Controlled by the autonomic nervous system, rather than the central nervous system, our brain runs the interstia below the level of consciousness.

Interstia has no nerves, Robert. The autonomic nervous system IS the central nervous system.

Im a BM wrote:
During our dreams, our autonomic nervous system does its best to communicate with the central nervous system.

The autonomic nervous system IS the central nervous system.

Im a BM wrote:
The connective tissue of the interstia

Has no nerves, Robert. Interstia is not connective tissue.

Im a BM wrote:
evolved primarily as a way to remove volatile toxic gases and dissolved or suspended toxins from the body, while allowing some oxygen to get in deeper than the hemoglobin in our blood vessels can adequately provide across tissues.

Salt water is not evolvement, Robert.

Im a BM wrote:
The interstia evacuates the toxins from the body by various routes.

It doesn't evacuate toxins from the body at all, Robert.

Im a BM wrote:
Another hugely important route by which the interstia gets bad crud out of our bodies is through the colon.

The colon is not intersia, Robert.

Im a BM wrote:
Another exit port for the interstia

Instertia is not a port, Robert.

Im a BM wrote:
to get bad stuff out of us is in the throat, connected to the sinuses and lungs. Right next to our tonsils. Toxic crud and foreign objects get caught up in thick mucus and then get evacuated into the throat. Many respiratory and sinus ailments are associated with it.

Interstia is not the throat, sinuses, lungs, nor mucus.

Im a BM wrote:
I predict that ten years from now, new students entering medical school will be given all this and it will result in much better medical treatments.

They know far more than you do, Robert, and they haven't even graduated yet.

Im a BM wrote:
Instead of just doping patients up with painkillers, turning off their immune responses with corticosteroids, and compensating with antibiotics.

You can't turn off the immune system, Robert, other than to die.

Spongy Iris wrote:
Bump with a song about the subject matter.

Saying goodbye to your soul.

Don't look back in anger.

Are there no music fans on this site??

I wonder if anybody realized the chords to this song are just one of countless variations of the famous Canon in D. These are more like Canon in C, tho.

You know, that's the song they play at every wedding.

Spongy Iris wrote:

Spongy Iris wrote:
Bump with a song about the subject matter.

Saying goodbye to your soul.

Don't look back in anger.

Are there no music fans on this site??

I wonder if anybody realized the chords to this song are just one of countless variations of the famous Canon in D. These are more like Canon in C, tho.

You know, that's the song they play at every wedding.

I just had to re-record my wedding singer troll song to bump my thread. I'm sure it won't take long to drown it again.

My soul has yet to slide away, cuz I can still smell the semen stuck up my ass, especially after a long walk on a hot day like today, followed by a jam session.

But at least I found my terrible voice a little bit better in the latest recording.

https://youtube.com/shorts/_oGkM9EUgCw?si=2Z7-n1jONI4Sgrew